Although biologics are usually given by injection or intravenous infusion, oral formulations might be possible. In general, oral drugs offer many benefits, from simplified distribution to overall cost reductions for patients, as well as being easier use and often have better patient compliance. Nonetheless, acids and enzymes in the stomach can degrade biologics even before they get absorbed, and the liver can eliminate biologics that survive the stomach. To address these challenges, scientists explore various routes to developing safe and effective oral delivery of biologics.
The most common approach to developing oral formulations of biologics depends on the delivery device. As one example, Joshua Myers, clinical research director at Rani Therapeutics, and his colleagues recently reported on an oral formulation of biologics to treat osteoporosis. That work used what Rani Therapeutics describes as a robotic pill, because it remains intact until it reaches the intestine, “where it delivers the…
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