Our immune system is divided into two main branches: innate and adaptive. Innate immune cells act as a first line of defense, quickly responding to invaders, while adaptive immune cells take a longer time to respond but take a more targeted and robust defense. In between these two branches, there lies a subset of immune cells known as innate-like T cells. Innate-like T cells contain characteristics of both innate and adaptive immunity, which make them potential candidates for developing new immunotherapies against diseases such as cancer. However, the mechanisms and developmental pathways of innate-like T cells in humans are not fully understood. Now, researchers from Cold Spring Harbor Laboratory (CSHL) and the University of Colorado Anschutz sought to uncover the mysteries of these cells. Their findings reveal differences in how innate-like T cells mature in humans and mice, with age playing a critical role.
The study is published in Cell…
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